[HTML][HTML] Overcoming resistance to endocrine therapy in breast cancer: new approaches to a nagging problem
YA Luqmani, N Alam-Eldin - Medical Principles and Practice, 2016 - karger.com
In the majority of women, breast cancer progresses through increased transcriptional activity
due to over-expressed oestrogen receptors (ER). Therapeutic strategies include:(i) reduction …
due to over-expressed oestrogen receptors (ER). Therapeutic strategies include:(i) reduction …
Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents
H Jia, Q Yang, T Wang, Y Cao, Q Jiang, H Sun… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background The rapid development of multi-drug resistance (MDR) process has hindered
the effectiveness of advanced hepatocellular carcinoma (HCC) treatments. Notch-1 …
the effectiveness of advanced hepatocellular carcinoma (HCC) treatments. Notch-1 …
Microenvironment‐induced TIMP2 loss by cancer‐secreted exosomal miR‐4443 promotes liver metastasis of breast cancer
J Wang, Q Zhang, D Wang, S Yang… - Journal of Cellular …, 2020 - Wiley Online Library
We aimed to investigate the role of exosomal miR‐4443 in metastasis of breast cancer
(BCa). In vitro wound‐healing assay and transwell invasion assay were used to investigate …
(BCa). In vitro wound‐healing assay and transwell invasion assay were used to investigate …
[HTML][HTML] Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update
Epithelial-to-mesenchymal transition (EMT) represents conversion of an epithelial cell in an
elongated cell with mesenchymal phenotype, which can occur in physiologic and pathologic …
elongated cell with mesenchymal phenotype, which can occur in physiologic and pathologic …
Synthesis of β-Carboline-Based N-Heterocyclic Carbenes and Their Antiproliferative and Antimetastatic Activities against Human Breast Cancer Cells
A series of novel β-carboline-based N-heterocyclic carbenes was prepared via Mannich
reaction between methyl 1-(dimethoxymethyl)-9 H-pyrido [3, 4-b] indole-3-carboxylate …
reaction between methyl 1-(dimethoxymethyl)-9 H-pyrido [3, 4-b] indole-3-carboxylate …
Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network
J Yang, Y Hou, M Zhou, S Wen, J Zhou, L Xu… - The international journal …, 2016 - Elsevier
Twist, a highly conserved basic Helix-Loop-Helix transcription factor, functions as a major
regulator of epithelial-mesenchymal transition (EMT) and tumor metastasis. In different cell …
regulator of epithelial-mesenchymal transition (EMT) and tumor metastasis. In different cell …
Recent progress in HER2 associated breast cancer
WJ Wang, YY Lei, JH Mei, CL Wang - Asian Pacific Journal of …, 2015 - koreascience.kr
Breast cancer is the most common cancer worldwide among women and the second most
common cancer. Approximately 15-23% of breast cancers over-express human epidermal …
common cancer. Approximately 15-23% of breast cancers over-express human epidermal …
Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter
Overexpression of drug efflux transporters is commonly associated with multidrug-resistance
in cancer therapy. Here for the first time, we investigated the ability of diindolylmethane …
in cancer therapy. Here for the first time, we investigated the ability of diindolylmethane …
Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis
Available breast cancer therapeutic strategies largely target the primary tumor but are
ineffective against tumor metastasis and angiogenesis. In our current study, we determined …
ineffective against tumor metastasis and angiogenesis. In our current study, we determined …
[HTML][HTML] Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options.
The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti …
The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti …