Gene conversion: mechanisms, evolution and human disease

JM Chen, DN Cooper, N Chuzhanova, C Férec… - Nature Reviews …, 2007 - nature.com
Gene conversion, one of the two mechanisms of homologous recombination, involves the
unidirectional transfer of genetic material from a'donor'sequence to a highly homologous' …

The role of folate receptor α in cancer development, progression and treatment: cause, consequence or innocent bystander?

LE Kelemen - International journal of cancer, 2006 - Wiley Online Library
Folate receptor α (FRα) is a membrane‐bound protein with high affinity for binding and
transporting physiologic levels of folate into cells. Folate is a basic component of cell …

Towards a cellular and molecular understanding of neurulation

JF Colas, GC Schoenwolf - Developmental dynamics: an …, 2001 - Wiley Online Library
Neurulation occurs during the early embryogenesis of chordates, and it results in the
formation of the neural tube, a dorsal hollow nerve cord that constitutes the rudiment of the …

[HTML][HTML] Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect

SP Rothenberg, MP da Costa… - … England Journal of …, 2004 - Mass Medical Soc
Background In the absence of clinical folate deficiency, periconceptional supplementation
with folic acid reduces a woman's risk of having an infant with a neural-tube defect. Since …

Importance of gene–environment interactions in the etiology of selected birth defects

H Zhu, S Kartiko, RH Finnell - Clinical genetics, 2009 - Wiley Online Library
It is generally understood that both genetic and environmental factors contribute to the highly
complex etiology of structural birth defects, including neural tube defects, oral clefts and …

[HTML][HTML] Folic acid supplementation and prevention of birth defects

NS Green - The Journal of nutrition, 2002 - Elsevier
Based on animal studies, epidemiologic studies and intervention trials, maternal folic acid is
known to be protective for neural tube defects (NTD), primarily spina bifida and …

Genetic and epigenetic contributions to human nutrition and health: managing genome–diet interactions

PJ Stover, MA Caudill - Journal of the American Dietetic Association, 2008 - Elsevier
The Institute of Medicine recently convened a workshop to review the state of the various
domains of nutritional genomics research and policy and to provide guidance for further …

[HTML][HTML] A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism

MC Reed, HF Nijhout, ML Neuhouser… - The Journal of …, 2006 - Elsevier
Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease
outcomes. A better understanding of the nutritional and genetic influences on this complex …

[HTML][HTML] Clinical recognition and aspects of the cerebral folate deficiency syndromes

V Ramaekers, JM Sequeira… - Clinical chemistry and …, 2013 - degruyter.com
We characterized cerebral folate deficiency (CFD) as any neuro-psychiatric condition
associated with low spinal fluid (CSF) N5-methyltetrahydrofolate (MTHF) but normal folate …

Molecular basis of environmentally induced birth defects

RH Finnell, JG Waes, JD Eudy… - Annual review of …, 2002 - annualreviews.org
Exposure of the developing conceptus to selected environmental agents can lead to
deleterious and often times lethal birth defects. These malformations result in serious …