Gene conversion, one of the two mechanisms of homologous recombination, involves the
unidirectional transfer of genetic material from a'donor'sequence to a highly homologous' …

Folate receptor α (FRα) is a membrane‐bound protein with high affinity for binding and
transporting physiologic levels of folate into cells. Folate is a basic component of cell …

Neurulation occurs during the early embryogenesis of chordates, and it results in the
formation of the neural tube, a dorsal hollow nerve cord that constitutes the rudiment of the …

Background In the absence of clinical folate deficiency, periconceptional supplementation
with folic acid reduces a woman's risk of having an infant with a neural-tube defect. Since …

It is generally understood that both genetic and environmental factors contribute to the highly
complex etiology of structural birth defects, including neural tube defects, oral clefts and …

Based on animal studies, epidemiologic studies and intervention trials, maternal folic acid is
known to be protective for neural tube defects (NTD), primarily spina bifida and …

The Institute of Medicine recently convened a workshop to review the state of the various
domains of nutritional genomics research and policy and to provide guidance for further …

Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease
outcomes. A better understanding of the nutritional and genetic influences on this complex …

We characterized cerebral folate deficiency (CFD) as any neuro-psychiatric condition
associated with low spinal fluid (CSF) N5-methyltetrahydrofolate (MTHF) but normal folate …

Exposure of the developing conceptus to selected environmental agents can lead to
deleterious and often times lethal birth defects. These malformations result in serious …