Whether vitamin C (ascorbate) has a role to play as an anti-cancer agent has been debated
for decades. Ascorbate has been used by cancer patients in an unregulated environment …

Hypoxia is a characteristic of many solid tumors and an adverse prognostic factor for
treatment outcome. Hypoxia increases the expression of carbonic anhydrase IX (CAIX), an …

Although similar phenotypically, there is evidence that male and female breast cancer differ
in their molecular landscapes. In this systematic review, we consolidated all existing …

Background The transcription factor hypoxia inducible factor (HIF)-1 drives tumor growth and
metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C ([C@ H](NC (=
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …

Breast cancer is one of the most common malignancies that seriously threaten women's
health. In the process of the malignant transformation of breast cancer, metabolic …

Simple Summary Male breast cancer (MBC) is a rare disease. Genetic factors predispose to
male breast cancer. Germline and/or genetic and/or epigenetic alterations at the somatic …

Male breast cancer (MBC) is an uncommon and poorly understood disease. Recent
molecular studies have shown important differences from female breast cancer which are …

Hypoxia and autophagy are known to facilitate tumor progression. We here aimed to
investigate the role of hypoxia-associated autophagy in cholangiocarcinoma (CCA) survival …