Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many
chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache …

Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with
hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in …

Clinical studies show that chronic pain is accompanied by memory deficits and reduction in
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …

Recurrent seizure activity has been shown to induce a variety of permanent structural
changes in the brain. Matrix metalloproteinases (MMPs) function to promote neuronal …

Neurotoxicity is the limiting side effect of the anticancer agent oxaliplatin. A tangled panel of
symptoms, sensory loss, paresthesia, dysesthesia, and pain may be disabling for patients …

Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle
features with hyperalgesia including induction protocols, pharmacological profile, neuronal …

Injury to the adult nervous system promotes the expression and secretion of brain-derived
neurotrophic factor (BDNF). Because it promotes neuronal growth, survival and …

It has been shown that following peripheral nerve injury brain-derived neurotrophic factor
(BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF …

Understanding neurite growth regulation remains a seminal problem in neurobiology.
During development and regeneration, neurite growth is modulated by neurotrophin …

Pain and fear are both aversive experiences that strongly impact on behaviour and well
being. They are considered protective when they lead to meaningful, adaptive behaviour …