The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Highlights•Actin polymerization on endosomes is primarily controlled by the regulation of the
WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and …

Actin filaments play multiple roles in the secretory pathway and in endosome dynamics in
mammals, including maintenance of Golgi structure, release of membrane cargo from the …

Mitochondria supply ATP essential for synaptic transmission. Neurons face exceptional
challenges in maintaining energy homoeostasis at synapses. Regulation of mitochondrial …

Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis
involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations …

Motor proteins are key players in exerting spatiotemporal control over the intracellular
location of membrane-bound compartments, including endosomes containing cargo. In this …

The myosin motor protein myosin VI plays an essential role in mammalian spermatogenesis,
however, the effects of myosin VI on male reproduction in Crustacea remain obscure. We …

The intracellular functions of myosin motors requires a number of adaptor molecules, which
control cargo attachment, but also fine‐tune motor activity in time and space. These motor …

Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how
neurotrophins regulate the endosomal system for proper signaling is unknown. Rabs are …

Myosins of class VI (MYO 6) are unique actin‐based motor proteins that move cargo towards
the minus ends of actin filaments. As the sole myosin with this directionality, it is critically …