The lysosomal compartment is essential for a variety of cellular functions, including the
normal turnover of most long-lived proteins and all organelles. The compartment consists of …

Abstract Microplastics (MPs) and nanoplastics (NPs) pollution has become an increasingly
serious environmental problem, drawing widespread attentions. Owing to the small size …

Autophagy is a catabolic pathway activated in response to different cellular stressors, such
as damaged organelles, accumulation of misfolded or unfolded proteins, ER stress …

We have investigated in detail the role of intra-organelle Ca 2+ content during induction of
apoptosis by the oxidant menadione while changing and monitoring the Ca 2+ load of …

Background Increasing environmental and occupational exposures to nanoparticles (NPs)
warrant deeper insight into the toxicological mechanisms induced by these materials. The …

The lysosomal compartment consists of numerous acidic vesicles (pH~ 4–5) that constantly
fuse and divide. It receives a large number of hydrolases from the trans-Golgi network, while …

Oxidative stress occurs in diabetes, various cancers, liver diseases, stroke, rheumatoid
arthritis, chronic inflammation, and other degenerative diseases related to the nervous …

Significance: Lysosomes are acidic organelles containing more than fifty hydrolases that
provide for the degradation of intracellular and endocytosed materials by autophagy and …

Abstract Aflatoxin B1 (AFB1) is a potent hepatotoxic and carcinogenic agent. Curcumin
possesses potential anti-inflammatory, anti-oxidative and hepatoprotective effects. However …

Multiple sevoflurane exposure may result in cognitive deficits in neonatal animals. This study
attempted to investigate the potential mechanism of sevoflurane-induced neurotoxicity in …