Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

Conspectus The development of palladium-catalyzed cross-coupling methods for the
activation of C (sp2)–Br bonds facilitated access to arene-rich molecules, enabling a …

Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …

Synergistic catalysis, a type of plural catalysis which utilizes at least two different catalysts to
enable a reaction between two separately activated substrates, has unlocked a plethora of …

Reactions that enable carbon–nitrogen, carbon–oxygen and carbon–carbon bond formation
lie at the heart of synthetic chemistry. However, substrate prefunctionalization is often …

Aryl halides are a fundamental motif in synthetic chemistry, playing a critical role in metal-
mediated cross-coupling reactions and serving as important scaffolds in drug discovery …

C–H bond activation and decarboxylation are two significant processes in organic synthesis.
The combination of these processes provides a novel synthetic strategy, that is …

Pd-catalyzed cross-coupling reactions have become essential tools for the construction of
carbon–carbon and carbon–heteroatom bonds. Over the last three decades, great efforts …

We report a copper-catalyzed strategy for arylboronic ester synthesis that exploits
photoinduced ligand-to-metal charge transfer (LMCT) to convert (hetero) aryl acids into aryl …

The formation of C–aryl bonds has been the focus of intensive research over the last
decades for the construction of complex molecules from simple, readily available feedstocks …