Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

Superoxide is a primary oxygen radical that is produced when an oxygen molecule receives
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …

Neurological disorders (ND) are the central nervous system (CNS) related complications
originated by enhanced oxidative stress, mitochondrial failure and overexpression of …

Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that
accumulate under normal physiological conditions and are stimulated by changes in the …

As a critical molecule in the onset and sustainment of inflammatory response, the receptor
for advanced glycation end products (RAGE) has a variety of ligands, such as advanced …

Idiopathic pulmonary fibrosis is characterised by abnormal reepithelialisation and
remodelling consequent to persistent stimuli or injury. The involvement of oxidative stress in …

The receptor for advanced glycation end products (RAGE) is a member of the
immunoglobulin family that is overexpressed in several cancers. RAGE is highly expressed …

Tumor microenvironments are often characterized by an increase in oxidative stress levels.
We studied the response to oxidative stimulation in human primary (IGR39) or metastatic …

The interior of the cell abounds with reactive species that can accumulate as non-enzymatic
covalent modifications (NECMs) on biological macromolecules. These adducts interfere with …

The receptor for advanced glycation end-products (RAGE) is a multiligand binding and
single-pass transmembrane protein which actively participates in several chronic …