Wounding the cornea to learn how it heals

MA Stepp, JD Zieske, V Trinkaus-Randall… - Experimental eye …, 2014 - Elsevier
Corneal wound healing studies have a long history and rich literature that describes the data
obtained over the past 70 years using many different species of animals and methods of …

Ocular toxicity of mustard gas: A concise review

A Fuchs, EA Giuliano, NR Sinha, RR Mohan - Toxicology letters, 2021 - Elsevier
Sulfur mustard (SM) is a chemical warfare agent that has been used throughout recent
history and remains a threat today. Exposed soldiers and civilians experience a variety of …

Nitrogen mustard-induced ex vivo human cornea injury model and therapeutic intervention by dexamethasone

N Mishra, R Kant, K Kandhari, DA Ammar… - … of Pharmacology and …, 2024 - ASPET
Sulfur mustard (SM), a vesicating agent first used during World War I, remains a potent threat
as a chemical weapon to cause intentional/accidental chemical emergencies. Eyes are …

The neuropeptide α-Melanocyte–Stimulating Hormone prevents persistent corneal edema following injury

H Alemi, S Wang, T Blanco, F Kahale, RB Singh… - The American Journal of …, 2024 - Elsevier
Corneal endothelial cells (CEnCs) regulate corneal hydration and maintain tissue
transparency through their barrier and pump function. However, these cells exhibit limited …

Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits

DG Goswami, N Mishra, R Kant, C Agarwal… - Plos one, 2021 - journals.plos.org
Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917;
corneas are particularly vulnerable to SM exposure. They may develop inflammation …

Establishing a Dexamethasone Treatment Regimen To Alleviate Sulfur Mustard–Induced Corneal Injuries in a Rabbit Model

N Mishra, R Kant, K Kandhari, N Tewari-Singh… - … of Pharmacology and …, 2024 - ASPET
Sulfur mustard (SM) is an ominous chemical warfare agent. Eyes are extremely susceptible
to SM toxicity; injuries include inflammation, fibrosis, neovascularization (NV), and vision …

Insights into mustard gas keratopathy-characterizing corneal layer-specific changes in mice exposed to nitrogen mustard

H Alemi, S Dehghani, K Forouzanfar, PL Surico… - Experimental eye …, 2023 - Elsevier
Exposure to mustard agents, such as sulfur mustard (SM) and nitrogen mustard (NM), often
results in ocular surface damage. This can lead to the emergence of various corneal …

Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model

DG Goswami, N Mishra, R Kant, C Agarwal… - Toxicology and applied …, 2022 - Elsevier
Nitrogen mustard (NM) is an analogue of the potent vesicating agent sulfur mustard, with
well-established ocular injury models in rabbit eyes to study vesicant-induced ocular toxicity …

Nano Self-Assemblies of Caffeic Acid–Fibronectin Mimic a Peptide Conjugate for the Treatment of Corneal Epithelial Injury

Y Wu, L Du, X Xu, Y Hu, J Liu, J Zhang… - Molecular …, 2023 - ACS Publications
Rapid corneal re-epithelialization is important for corneal wound healing. Corneal epithelial
cell motility and oxidative stress are important targets for therapeutic intervention. In this …

Mustard Gas Exposure Actuates SMAD2/3 Signaling to Promote Myofibroblast Generation in the Cornea

NR Sinha, R Tripathi, PK Balne, L Suleiman, K Simkins… - Cells, 2023 - mdpi.com
Sulfur mustard gas (SM) is a vesicating and alkylating agent used as a chemical weapon in
many mass-casualty incidents since World War I. Ocular injuries were reported in> 90% of …