Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …

In many clinical pain syndromes, painful sensations are greatly amplified so that normally
innocuous sensations, such as light touch or warmth, are perceived as pain. Presently …

Disturbance to early brain development is implicated in several neuropsychiatric disorders
including autism, schizophrenia, and mental retardation. Epidemiological studies have …

Neuroimmune diseases have diverse symptoms and etiologies but all involve pathological
inflammation that affects normal central nervous system signaling. Critically, many …

The transcription factor NF-κB has diverse functions in the nervous system, depending on
the cellular context. NF-κB is constitutively activated in glutamatergic neurons. Knockout of …

Interleukin (IL)-10 is synthesized in the central nervous system (CNS) and acts to limit
clinical symptoms of stroke, multiple sclerosis, Alzheimer's disease, meningitis, and the …

Recently, it was found that microglia regulated synaptic remodeling of the developing brain,
but their mechanisms have not been well understood. In this study, the action of microglia on …

Tolerance to the analgesic effect of an opioid is a pharmacological phenomenon that occurs
after its prolonged administration. Activation of the NMDA receptor (NMDAR) has been …

Nuclear factor kappa B (NF-κB) is an inducible transcription factor present in neurons and
glia. Recent genetic models identified a role for NF-κB in neuroprotection against various …

Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United
States. A potential treatment for decreasing the secondary inflammation, excitotoxic damage …