Natural products possess structural complexity, diversity and chirality with attractive
functions and biological activities that have significantly impacted drug discovery initiatives …

Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …

Dengue remains one of the most serious and widespread mosquito‐borne viral infections in
human beings, with serious health problems or even death. About 50 to 100 million people …

Abstract NS2B-NS3 is a serine protease of the Dengue virus considered a key target in the
search for new antiviral drugs. In this study flavonoids were found to be inhibitors of NS2B …

While dengue virus (DENV) infection imposes a serious challenge to the survival of humans
worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most …

Dengue is a tropical disease caused by the Dengue virus (DENV), a positive-sense, single
stranded RNA virus of the family Flaviviridae, which is transmitted by Aedes mosquitoes. The …

For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …

The potential therapeutic effect of Carica papaya leaf juice has attracted wide interest from
the public and scientists in relieving dengue related manifestations. Currently, there is a lack …

Abstract Development of anti-dengue therapy represents an urgent un-met medical need.
Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led …

Dengue has become a global affliction despite continuous efforts to find cure for this age-old
disease. Hopeful results for dengue vaccine are far-fetched as the effectiveness are tied to …