Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

A Wu, J Zhang - Journal of Neuroinflammation, 2023 - Springer
As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Regulation of cellular processes by interleukin‐16 in homeostasis and cancer

J Richmond, M Tuzova, W Cruikshank… - Journal of cellular …, 2014 - Wiley Online Library
Abstract Interleukin‐16 (IL‐16) is generated as a precursor molecule that is cleaved by
caspase‐3 to produce a pro‐IL‐16 molecule that functions as a regulator of T cell growth …

Hepatopancreas immune response during molt cycle in the mud crab, Scylla paramamosain

Z Xu, A Liu, S Li, G Wang, H Ye - Scientific Reports, 2020 - nature.com
Molt is a critical developmental process in crustaceans. Recent studies have shown that the
hepatopancreas is an important source of innate immune molecules, yet hepatopancreatic …

Shared brain connectivity issues, symptoms, and comorbidities in autism spectrum disorder, attention deficit/hyperactivity disorder, and Tourette syndrome

JK Kern, DA Geier, PG King, LK Sykes, JA Mehta… - Brain …, 2015 - liebertpub.com
The prevalence of neurodevelopmental disorders, including autism spectrum disorder
(ASD), attention deficit/hyperactivity disorder (ADHD), and Tourette syndrome (TS), has …

Isolation of microglia-derived extracellular vesicles: towards miRNA signatures and neuroprotection

Q Lemaire, A Raffo-Romero, T Arab… - Journal of …, 2019 - Springer
The functional preservation of the central nervous system (CNS) is based on the neuronal
plasticity and survival. In this context, the neuroinflammatory state plays a key role and …

A comparative biology of microglia across species

K Sharma, K Bisht, UB Eyo - Frontiers in cell and developmental …, 2021 - frontiersin.org
Microglia are unique brain-resident, myeloid cells. They have received growing interest for
their implication in an increasing number of neurodevelopmental, acute injury, and …

Proteomic characterisation of leech microglia extracellular vesicles (EVs): comparison between differential ultracentrifugation and Optiprep™ density gradient isolation

T Arab, A Raffo-Romero, C Van Camp… - Journal of …, 2019 - Taylor & Francis
In Mammals, microglial cells are considered as the resident immune cells in central nervous
system (CNS). Many studies demonstrated that, after injury, these cells are activated and …

Microglia of medicinal leech (Hirudo medicinalis) express a specific activation marker homologous to vertebrate ionized calcium‐binding adapter molecule 1 (Iba1 …

F Drago, PE Sautière, F Le Marrec‐Croq… - Developmental …, 2014 - Wiley Online Library
ABSTRACT The Ionized calcium‐Binding Adapter molecule 1 (Iba1), also known as Allograft
Inflammatory Factor 1 (AIF‐1), is a 17 kDa cytokine‐inducible protein, produced by activated …

Medicinal leech CNS as a model for exosome studies in the crosstalk between microglia and neurons

A Raffo-Romero, T Arab, IS Al-Amri… - International journal of …, 2018 - mdpi.com
In healthy or pathological brains, the neuroinflammatory state is supported by a strong
communication involving microglia and neurons. Recent studies indicate that extracellular …

Identification and characterization of an interleukin-16-like gene from pacific white shrimp Litopenaeus vannamei

Q Liang, J Zheng, H Zuo, C Li, S Niu, L Yang… - Developmental & …, 2017 - Elsevier
Interleukins are a group of cytokines that play essential roles in immune regulation. Almost
all interleukin genes are only found in vertebrates. In this study, an interleukin-16-like gene …