The metal-catalyzed asymmetric conjugate addition (ACA) reaction has emerged as a
general and powerful approach for the construction of optically active compounds and is …

The design and development of new high‐performance catalysts for applications in
asymmetric catalytic reactions is of ongoing interest in organic chemistry. The combination of …

Enantioselective catalytic formation of tertiary stereogenic centers has nowadays reached
an impressive level of maturity, as is reflected in the large variety of available methods that …

The design and application of linked-BINOLs investigated in our group are reviewed. Linked-
BINOLs are a kind of semi-crown ether, thus they are flexible and applicable to metals …

Zinc is the 24th most abundant element in the Earth's crust. Since the discovery of pure zinc
metal in the 18th century, the main application of zinc metal is as materials. Because zinc …

The conjugate addition of carbon nucleophiles to acceptor activated olefins is one of the
most important reactions for carbon-carbon bond formation. With optically active metal …

An enantioselective intramolecular Conia-ene reaction of β-dicarbonyl compounds and
alkynes to afford methylene cyclopentanes is described. The reaction employs a …

An anti-selective direct catalytic asymmetric Mannich-type reaction is described. The
Et2Zn/(S, S)-linked-BINOL 1= 4/1 complex promoted a Mannich-type reaction of 2-hydroxy-2 …

The first example of catalytic enantioselective nucleophilic aromatic substitution of β-
dicarbonyl compounds is presented. An O-benzoylated cinchona alkaloid derivative catalyst …

Full details of a direct catalytic asymmetric Mannich-type reaction of a hydroxyketone using a
Et2Zn/(S, S)-linked-BINOL complex are described. By choosing the proper protective groups …