A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
K Das, E Belnoue, M Rossi, T Hofer… - Nature …, 2021 - nature.com
Functional tumor-specific cytotoxic T cells elicited by therapeutic cancer vaccination in
combination with oncolytic viruses offer opportunities to address resistance to checkpoint …
combination with oncolytic viruses offer opportunities to address resistance to checkpoint …
A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition
E Heilmann, F Costacurta, S Geley… - Communications …, 2022 - nature.com
Protease inhibitors are among the most powerful antiviral drugs. However, for SARS-CoV-2
only a small number of protease inhibitors have been identified thus far and there is still a …
only a small number of protease inhibitors have been identified thus far and there is still a …
Mcl-1 Protein and Viral Infections: A Narrative Review
Z Wyżewski, J Stępkowska, AM Kobylińska… - International Journal of …, 2024 - mdpi.com
MCL-1 is the prosurvival member of the Bcl-2 family. It prevents the induction of
mitochondria-dependent apoptosis. The molecular mechanisms dictating the host cell …
mitochondria-dependent apoptosis. The molecular mechanisms dictating the host cell …
A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases
ABSTRACT SARS-CoV-2 has caused a global pandemic with significant humanity and
economic loss since 2020. Currently, only limited options are available to treat SARS-CoV-2 …
economic loss since 2020. Currently, only limited options are available to treat SARS-CoV-2 …
Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
L Krismer, H Schöppe, S Rauch, D Bante, B Sprenger… - npj Viruses, 2024 - nature.com
Abstract The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic,
zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has …
zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has …
Vesicular stomatitis virus as a platform for protease activity measurements
S Rauch, F Costacurta, D von Laer… - Current …, 2024 - Wiley Online Library
Protease inhibitors are among the most powerful antiviral drugs. They have been used
successfully against viruses, such as the human immunodeficiency virus (HIV), hepatitis C …
successfully against viruses, such as the human immunodeficiency virus (HIV), hepatitis C …
Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core
M Bessonne, J Morel, Q Nevers, B Da Costa… - PLoS …, 2024 - journals.plos.org
Influenza viruses transcribe and replicate their genome in the nucleus of the infected cells,
two functions that are supported by the viral RNA-dependent RNA-polymerase (FluPol) …
two functions that are supported by the viral RNA-dependent RNA-polymerase (FluPol) …
An HPLC-SEC-based rapid quantification method for vesicular stomatitis virus particles to facilitate process development
A Schimek, JKM Ng, I Basbas, F Martin, D Xin… - … Therapy Methods & …, 2024 - cell.com
Virus particle (VP) quantification plays a pivotal role in the development of production
processes of VPs for virus-based therapies. The yield based on total VP count serves as a …
processes of VPs for virus-based therapies. The yield based on total VP count serves as a …
Nanopore assay reveals cell-type-dependent gene expression of vesicular stomatitis indiana virus and differential host cell response
Vesicular stomatitis Indiana virus (VSIV) of genus Vesiculovirus, species Indiana
Vesiculovirus (formerly as Vesicular stomatitis virus, VSV) causes a disease in livestock that …
Vesiculovirus (formerly as Vesicular stomatitis virus, VSV) causes a disease in livestock that …
The Multiplicity of Infection of Recombinant Vaccinia Virus Expressing the T7 RNA Polymerase Determines the Rescue Efficiency of Vesicular Stomatitis Virus
F Yang, J Tan, Y Fang, G Chen, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Vesicular stomatitis virus (VSV) has a wide range of cell tropism, making it a prototype of
studying the negative-strand RNA virus (NSRV), including virus–host interactions and …
studying the negative-strand RNA virus (NSRV), including virus–host interactions and …