Nitric Oxide Donors: Chemical Activities and Biological Applications | Chemical Reviews ACS
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During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial
signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune …

Abstract Myeloid Derived Suppressor Cells (MDSC) are a heterogeneous population of
immature myeloid cells that are increased in states of cancer, inflammation and infection. In …

The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs
(NSAIDs) have led to the development of numerous Cu (II) complexes of NSAIDs with …

Tumor-associated macrophages are increasingly viewed as a target of great relevance in
the tumor microenvironment, because of their important role in cancer progression and …

The objective of this study was to elucidate the mechanisms by which nitric oxide (NO)
inhibits rat aortic smooth muscle cell (RASMC) proliferation. Two products of the arginine …

Cancer immunotherapy relies on either restoring or activating the function of adaptive
immune cells, mainly CD8+ T lymphocytes. Despite impressive clinical success, cancer …

Active suppression of tumor-specific T lymphocytes can limit the immune-mediated
destruction of cancer cells. Of the various strategies used by tumors to counteract immune …

3-4-(2-Fluoro-α-methyl-[1, 1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-
nitrooxy butyl ester (NCX-2216), a nitric oxide (NO)-releasing derivative of the …

Myeloid cells are the most abundant cells in the tumor microenvironment (TME). The tumor
recruits and modulates endogenous myeloid cells to tumor-associated macrophages (TAM) …