The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …

The Hippo-signaling pathway is an important regulator of cellular proliferation and organ
size. However, little is known about the role of this cascade in the control of cell fate …

Abstract The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled
receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as …

Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration
and maintenance but also promotes development of hepatocellular carcinoma (HCC) …

Adult liver progenitor cells are biliary-like epithelial cells that emerge only under injury
conditions in the periportal region of the liver. They exhibit phenotypes of both hepatocytes …

Transdifferentiation is a complete and stable change in cell identity that serves as an
alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …