Abstract Purpose of Review The past decade in LGL leukemia research has seen increased
pairing of clinical data with molecular markers, shedding new insights on LGL leukemia …

Large granular lymphocyte (LGL) leukemia, a rare hematologic malignancy, has long been
associated with rheumatoid arthritis (RA), and the diseases share numerous common …

T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of
mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common …

Benign clonal T-cell expansions in reactive immune responses often complicate the
laboratory diagnosis T-cell neoplasia. We recently introduced a novel flow cytometry assay …

Abstract Large Granular Lymphocyte Leukemia (LGLL) is a rare chronic lymphoproliferative
disorder characterized by the clonal expansion of Large Granular Lymphocytes (LGLs) …

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disorder of older adults
characterized by the clonal expansion of cytotoxic T/natural killer cells due to constitutive pro …

In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in
the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells …

The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-
cells in vitro. However, in some dasatinib-treated leukemia patients, clonal lymphocytosis …

Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic
T lymphocytes or CD3− natural killer (NK) cells. Chronic antigen stimulation is postulated to …

Large granular lymphocyte leukemia (LGLL) is a chronic lymphoproliferative disorder
characterized by the proliferation of T or NK cytotoxic cells in the peripheral blood, the …