The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Radiotherapy with high-energy charged particles has become an attractive therapeutic
option for patients with several tumour types because this approach better spares healthy …

Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very
effective in cell killing in the target region (tumour). In this regard, ions heavier than protons …

Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

Radiotherapy (RT) aims to deliver a spatially conformal dose of radiation to tumours while
maximizing the dose sparing to healthy tissues. However, the internal patient anatomy is …

The use of charged particle therapy to control tumours non-invasively offers advantages
over conventional radiotherapy. Protons and heavy ions deposit energy far more selectively …

The problem of respiratory motion has proved a serious obstacle in developing techniques
to acquire images or guide interventions in abdominal and thoracic organs. Motion models …

Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …

Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT,
represents the latest advanced PT technology for treating cancers, including thoracic …

In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has
shown rapid progress and widespread use in recent years—in multidisciplinary treatment …