Caspases are a family of cysteine proteases that predominantly cleave their substrates after
aspartic acid residues. Much of what we know of caspases emerged from investigation a …

EAAT2 is a high affinity, Na+-dependent glutamate transporter with predominant astroglial
localization. It accounts for the clearance of the bulk of glutamate released at central nervous …

Innate neuroinflammatory changes, increased oxidative stress and disorders of glutathione
metabolism may be involved in the pathophysiology of autism spectrum disorders (ASD) …

Background Existing methods for predicting protein solubility on overexpression in
Escherichia coli advance performance by using ensemble classifiers such as two-stage …

Caspase‐3 has classically been defined as the main executioner of programmed cell death.
However, recent data supports the participation of this protease in non‐apoptotic cellular …

Glioblastomas, the most malignant of all brain tumors, are characterized by cellular
resistance to apoptosis and a highly invasive growth pattern. These factors contribute to the …

Dysregulation of glutamate handling ensuing downregulation of expression and activity
levels of the astroglial glutamate transporter EAAT2 is implicated in excitotoxic degeneration …

The intrinsic apoptotic pathway is essential for murine development. We have previously
shown that key mediators of this pathway, such as Bim, Apaf-1 and caspase-3, are down …

Adverse early life experiences can increase the risk of psychiatric and neurological
disorders as the result of interference with brain development and maturation. In the present …

Cleaved caspase-3 (CC3) is well known as an executioner protease of apoptosis following
brain ischemia. However, an increasing body of evidence suggests several non-apoptotic …