Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
[HTML][HTML] Advances in chemical protein modification
O Boutureira, GJL Bernardes - Chemical reviews, 2015 - ACS Publications
Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …
modified proteins. The complementary use of both genetic and chemical methods has …
Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering
Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for
sustained protein release, targeted drug delivery, and tissue engineering due to excellent …
sustained protein release, targeted drug delivery, and tissue engineering due to excellent …
[HTML][HTML] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …
respectively, are produced during normal cell function and in response to various stimuli. An …
Spatiotemporal hydrogel biomaterials for regenerative medicine
Hydrogels mimic many of the physical properties of soft tissue and are widely used
biomaterials for tissue engineering and regenerative medicine. Synthetic hydrogels have …
biomaterials for tissue engineering and regenerative medicine. Synthetic hydrogels have …
Achieving controlled biomolecule–biomaterial conjugation
The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …
modulate specific cell behaviors. While the biological roles of particular polypeptide …
Interaction chemistry of functional groups for natural biopolymer-based hydrogel design
The exploration and development of natural biopolymer-based hydrogels can be traced
back to the 18th century. The rising interest in these hydrogels is largely due to their soaring …
back to the 18th century. The rising interest in these hydrogels is largely due to their soaring …
Hydrogels for protein delivery
Importantly, with the advent of hybridoma and recombinant DNA technologies, the limitations
associated with the extraction and purification of pharmaceutical proteins from animal …
associated with the extraction and purification of pharmaceutical proteins from animal …
Thiol–ene click chemistry
CE Hoyle, CN Bowman - Angewandte Chemie International …, 2010 - Wiley Online Library
Following Sharpless′ visionary characterization of several idealized reactions as click
reactions, the materials science and synthetic chemistry communities have pursued …
reactions, the materials science and synthetic chemistry communities have pursued …
Hydrogels in regenerative medicine
Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of
constituents, and desirable physical characteristics, have been the material of choice for …
constituents, and desirable physical characteristics, have been the material of choice for …