Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings
Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
Germline genetic contribution to the immune landscape of cancer
Understanding the contribution of the host's genetic background to cancer immunity may
lead to improved stratification for immunotherapy and to the identification of novel …
lead to improved stratification for immunotherapy and to the identification of novel …
Prenatal immune challenge in mice leads to partly sex-dependent behavioral, microglial, and molecular abnormalities associated with schizophrenia
CW Hui, A St-Pierre, H El Hajj, Y Remy… - Frontiers in molecular …, 2018 - frontiersin.org
Epidemiological studies revealed that environmental factors comprising prenatal infection
are strongly linked to risk for later development of neuropsychiatric disorders such as …
are strongly linked to risk for later development of neuropsychiatric disorders such as …
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease
A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the
course that the disease takes over time (progression and prognosis). To assess how genetic …
course that the disease takes over time (progression and prognosis). To assess how genetic …
Exploring the role of AMPA receptor auxiliary proteins in synaptic functions and diseases
α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) ionotropic glutamate
receptors (AMPARs) mediate rapid excitatory synaptic transmission in the mammalian brain …
receptors (AMPARs) mediate rapid excitatory synaptic transmission in the mammalian brain …
Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: a genome-wide association study and meta-analysis
HJ Li, C Zhang, L Hui, DS Zhou, Y Li, CY Zhang… - JAMA …, 2021 - jamanetwork.com
Importance The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully
understood. Objective To explore the genetic basis of BD in the Han Chinese population …
understood. Objective To explore the genetic basis of BD in the Han Chinese population …
Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models
The excitability of interneurons requires Nav1. 1, the α subunit of the voltage-gated sodium
channel. Nav1. 1 deficiency and mutations reduce interneuron excitability, a major …
channel. Nav1. 1 deficiency and mutations reduce interneuron excitability, a major …
Genetic analysis of six transmembrane protein family genes in Parkinson's disease in a large Chinese cohort
Y Zhao, K Zhang, H Pan, Y Wang, X Zhou… - Frontiers in Aging …, 2022 - frontiersin.org
Objectives Parkinson's disease (PD) is a neurodegenerative disorder with the manifestation
of motor symptoms and non-motor symptoms. Previous studies have indicated the role of …
of motor symptoms and non-motor symptoms. Previous studies have indicated the role of …
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
Oxidative stress impairs cognitive function by affecting hippocampal fimbria volume in drug-naïve, first-episode schizophrenia
R Jia, X Yuan, X Zhang, P Song, S Han… - Frontiers in …, 2023 - frontiersin.org
Objective The aim of the present study was to explore influencing factors of cognitive
impairments and their interrelationships in drug-naïve, first-episode schizophrenia (SCZ) …
impairments and their interrelationships in drug-naïve, first-episode schizophrenia (SCZ) …