Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …

The human genome contains more than 200,000 gene isoforms. However, different isoforms
can be highly similar, and with an average length of 1.5 kb remain difficult to study with short …

In cancer, fusions are important diagnostic markers and targets for therapy. Long-read
transcriptome sequencing allows the discovery of fusions with their full-length isoform …

Simple Summary Glioblastoma is a devastating malignancy that has continued to prove
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …

Genes generate transcripts of various functions by alternative splicing. However, in most
transcriptome studies, short-reads sequencing technologies (next-generation sequencers) …

Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently,
tumour heterogeneity and mutation acquisition are major impedances for tailoring …

The search for tumor-specific antigens (TSAs) has considerably accelerated during the past
decade due to the improvement of proteogenomic detection methods. This provides new …

Androgens are steroid hormones governing the male reproductive development and
function. As such, androgens and the key mediator of their effects, androgen receptor (AR) …

In the past decade, genomics has fundamentally changed our view of cancer biology,
allowing comprehensive analyses of mutations, copy number alterations, structural variants …