Basic mechanisms of cardiac impulse propagation and associated arrhythmias
AG Kléber, Y Rudy - Physiological reviews, 2004 - journals.physiology.org
Kléber, André G., and Yoram Rudy. Basic Mechanisms of Cardiac Impulse Propagation and
Associated Arrhythmias. Physiol Rev 84: 431–488, 2004; 10.1152/physrev. 00025.2003 …
Associated Arrhythmias. Physiol Rev 84: 431–488, 2004; 10.1152/physrev. 00025.2003 …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Ionic mechanisms of propagation in cardiac tissue: roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling
RM Shaw, Y Rudy - Circulation research, 1997 - Am Heart Assoc
In cardiac tissue, reduced membrane excitability and reduced gap junction coupling both
slow conduction velocity of the action potential. However, the ionic mechanisms of slow …
slow conduction velocity of the action potential. However, the ionic mechanisms of slow …
Electrospun fine-textured scaffolds for heart tissue constructs
X Zong, H Bien, CY Chung, L Yin, D Fang, BS Hsiao… - Biomaterials, 2005 - Elsevier
The structural and functional effects of fine-textured matrices with sub-micron features on the
growth of cardiac myocytes were examined. Electrospinning was used to fabricate …
growth of cardiac myocytes were examined. Electrospinning was used to fabricate …
Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle
Structural and functional cardiac anisotropy varies with the development, location, and
pathophysiology in the heart. The goal of this study was to design a cell culture model …
pathophysiology in the heart. The goal of this study was to design a cell culture model …
Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth
MS Spach, JF Heidlage, PC Dolber, RC Barr - Circulation research, 2000 - Am Heart Assoc
The increased incidence of arrhythmias in structural heart disease is accompanied by
remodeling of the cellular distribution of gap junctions to a diffuse pattern like that of …
remodeling of the cellular distribution of gap junctions to a diffuse pattern like that of …
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell–derived cardiac myocyte monolayers
Rationale: Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) offer a
powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug …
powerful in vitro tool to investigate disease mechanisms and to perform patient-specific drug …
Flexible electrical recording from cells using nanowire transistor arrays
Semiconductor nanowires (NWs) have unique electronic properties and sizes comparable
with biological structures involved in cellular communication, thus making them promising …
with biological structures involved in cellular communication, thus making them promising …
Fibrous scaffolds for building hearts and heart parts
Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that
promote and regulate tissue growth, function, and repair. From a structural perspective, the …
promote and regulate tissue growth, function, and repair. From a structural perspective, the …
Electrospun nanofibers as a tool for architecture control in engineered cardiac tissue
This paper presents an in vitro system for cardiac tissue engineering based on
cardiomyocytes cultured on electrospun polymethylglutarimide (PMGI) nanofibrous meshes …
cardiomyocytes cultured on electrospun polymethylglutarimide (PMGI) nanofibrous meshes …