Genetics of Alzheimer disease

LM Bekris, CE Yu, TD Bird… - Journal of geriatric …, 2010 - journals.sagepub.com
Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

[HTML][HTML] Genetic aspects of Alzheimer disease

TD Bird - Genetics in Medicine, 2008 - Elsevier
Alzheimer disease is the most common cause of dementia and represents a major public
health problem. The neuropathologic findings of amyloid-β plaques and tau containing …

[HTML][HTML] Linguistic markers predict onset of Alzheimer's disease

E Eyigoz, S Mathur, M Santamaria, G Cecchi… - …, 2020 - thelancet.com
Background The aim of this study is to use classification methods to predict future onset of
Alzheimer's disease in cognitively normal subjects through automated linguistic analysis …

Risk of dementia among white and African American relatives of patients with Alzheimer disease

RC Green, LA Cupples, R Go, KS Benke, T Edeki… - Jama, 2002 - jamanetwork.com
ContextEvidence exists that the incidence of Alzheimer disease (AD), as well as risk
attributable to specific genetic factors such as apolipoprotein E (APOE) genotype, may vary …

Cholinergic markers in elderly patients with early signs of Alzheimer disease

KL Davis, RC Mohs, D Marin, DP Purohit, DP Perl… - Jama, 1999 - jamanetwork.com
ContextA central tenet of Alzheimer disease (AD) is the loss of cortical cholinergic function
and cholinergic markers in postmortem brain specimens. Whether these profound deficits in …

Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?

NT Lautenschlager, LA Cupples, VS Rao… - Neurology, 1996 - AAN Enterprises
Article abstract-Despite recent advances in the molecular genetics of Alzheimer's disease
(AD), several fundamental questions concerning risk of illness are unresolved, namely, if …

Epidemiology of dementia and Alzheimer's disease

HC Hendrie - The American Journal of Geriatric Psychiatry, 1998 - Elsevier
The prevalence of dementia in subjects 65 years and older in North America is
approximately 6%–10%, with Alzheimer's disease (AD) accounting for two-thirds of these …

[HTML][HTML] Alzheimer disease overview

TD Bird - GeneReviews®[Internet], 2018 - ncbi.nlm.nih.gov
Alzheimer Disease Overview - GeneReviews® - NCBI Bookshelf US flag An official website of
the United States government Here's how you know NIH NLM Logo Access keys NCBI …

Molecular genetics of Alzheimer's disease

PH St George-Hyslop - Biological psychiatry, 2000 - Elsevier
Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

RE Davis, S Miller, C Herrnstadt… - Proceedings of the …, 1997 - National Acad Sciences
Mounting evidence suggests that defects in energy metabolism contribute to the
pathogenesis of Alzheimer disease (AD). Cytochrome c oxidase (CO) is kinetically …