It is generally accepted that both dysfunction of the Wnt signaling pathway, including
mutations in the adenomatous polyposis coli (APC) and β‐catenin genes, and genetic …

OBJECTIVES: Nonpolypoid colorectal neoplasms (NP-CRNs) are proposed as a major
contributor to the occurrence of interval cancers, but their underlying biology remains …

Primary synovial sarcoma (SS) of the lung is rare and may create diagnostic challenges. We
reviewed 11 cases of pulmonary SS (PSS) confirmed by the presence of a tumor-specific …

Aberrant activation of the Wnt signaling pathway has been implicated in tumorigenesis of a
wide range of tumors, including colorectal cancer. Regarding endometrial stromal tumors …

The molecular basis of carcinogenesis in gastrointestinal carcinoid tumors is not well
understood. To clarify the contribution of the Wnt/β-catenin signaling to this type of …

To elucidate the relationship between genetic alterations and cellular phenotypes in
differentiated‐type carcinomas and precancerous lesions of the stomach, mutations of p53 …

It is unclear whether the mutation spectra in WNT genes vary among distinct types of
colorectal tumors. We have analyzed mutations in specific WNT genes in a cohort of 52 …

Transforming growth factor (TGF)-β is a protein family which affects multiple cellular
functions including survival, proliferation, differentiation and adhesion. Among the three …

Abstract Purpose The Hedgehog (Hh) and pERK1/2 pathways participate in the
tumorigenesis of various tissues, but there has been no report on the involvement of these …

Introduction 3. Mechanism of mismatch repair (MMR) 3.1. Overview of methyl-directed MMR
in Escherichia. coli 3.2. Overview of MMR in human cells 4. MMR deficiency and colorectal …