Beyond plasticity: the dynamic impact of electrical synapses on neural circuits

P Alcamí, AE Pereda - Nature Reviews Neuroscience, 2019 - nature.com
Electrical synapses are found in vertebrate and invertebrate nervous systems. The cellular
basis of these synapses is the gap junction, a group of intercellular channels that mediate …

[HTML][HTML] Electrical synapses in mammalian CNS: Past eras, present focus and future directions

JI Nagy, AE Pereda, JE Rash - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Gap junctions provide the basis for electrical synapses between neurons. Early studies in
well-defined circuits in lower vertebrates laid the foundation for understanding various …

[HTML][HTML] Role of olivary electrical coupling in cerebellar motor learning

RS Van Der Giessen, SK Koekkoek, S van Dorp… - Neuron, 2008 - cell.com
The level of electrotonic coupling in the inferior olive is extremely high, but its functional role
in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary …

[HTML][HTML] Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network

GP Dugué, N Brunel, V Hakim, E Schwartz, M Chat… - Neuron, 2009 - cell.com
Tonic motor control involves oscillatory synchronization of activity at low frequency (5–30
Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the …

Neuronal gap junctions: making and breaking connections during development and injury

AB Belousov, JD Fontes - Trends in neurosciences, 2013 - cell.com
In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (ie,
electrical synapses) and the expression of the neuronal gap junction protein, connexin 36 …

Electrical synapses control hippocampal contributions to fear learning and memory

S Bissiere, M Zelikowsky, R Ponnusamy, NS Jacobs… - Science, 2011 - science.org
The role of electrical synapses in synchronizing neuronal assemblies in the adult
mammalian brain is well documented. However, their role in learning and memory …

Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity

AG Shaikh, S Hong, K Liao, J Tian, D Solomon, DS Zee… - Brain, 2010 - academic.oup.com
The inferior olivary nuclei clearly play a role in creating oculopalatal tremor, but the exact
mechanism is unknown. Oculopalatal tremor develops some time after a lesion in the brain …

Cerebellar inhibitory input to the inferior olive decreases electrical coupling and blocks subthreshold oscillations

Y Lefler, Y Yarom, MY Uusisaari - Neuron, 2014 - cell.com
GABAergic projection neurons in the cerebellar nuclei (CN) innervate the inferior olive (IO)
that in turn is the source of climbing fibers targeting Purkinje neurons in the cerebellar …

The computational power of the human brain

PJ Gebicke-Haerter - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
At the end of the 20th century, analog systems in computer science have been widely
replaced by digital systems due to their higher computing power. Nevertheless, the question …

[HTML][HTML] Harmaline tremor: underlying mechanisms in a potential animal model of essential tremor

A Handforth - Tremor and other hyperkinetic movements, 2012 - ncbi.nlm.nih.gov
Background Harmaline and harmine are tremorigenic β-carbolines that, on administration to
experimental animals, induce an acute postural and kinetic tremor of axial and truncal …