[HTML][HTML] TLRs: innate immune sentries against SARS-CoV-2 infection
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …
Innate virus-sensing pathways in B cell systemic autoimmunity
CG Vinuesa, A Grenov, G Kassiotis - Science, 2023 - science.org
Although all multicellular organisms have germ line–encoded innate receptors to sense
pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based …
pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based …
[HTML][HTML] A second update on mapping the human genetic architecture of COVID-19
M Kanai, SJ Andrews, M Cordioli, C Stevens, BM Neale… - Nature, 2023 - nature.com
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …
inform our understanding of the underlying biological mechanisms that influence adverse …
[HTML][HTML] HLA variation and SARS-CoV-2 specific antibody response
D Wolday, CYJ Fung, G Morgan, S Casalino… - Viruses, 2023 - mdpi.com
Differences in SARS-CoV-2-specific immune responses have been observed between
individuals following natural infection or vaccination. In addition to already known factors …
individuals following natural infection or vaccination. In addition to already known factors …
[HTML][HTML] Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
D Matuozzo, E Talouarn, A Marchal, P Zhang, J Manry… - Genome medicine, 2023 - Springer
Background We previously reported that impaired type I IFN activity, due to inborn errors of
TLR3-and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …
TLR3-and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …
[HTML][HTML] Human genomics of COVID-19 pneumonia: Contributions of rare and common variants
A Cobat, Q Zhang… - Annual review of …, 2023 - annualreviews.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …
[HTML][HTML] Genetic susceptibility to severe COVID-19
C Cappadona, V Rimoldi, EM Paraboschi… - Infection, Genetics and …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the
coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of the disease …
coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of the disease …
[HTML][HTML] Three-year outcomes of post-acute sequelae of COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-
acute sequelae of coronavirus disease 2019 (COVID-19)(PASC) in many organ systems …
acute sequelae of coronavirus disease 2019 (COVID-19)(PASC) in many organ systems …
[HTML][HTML] Host genetic risk factors associated with COVID-19 susceptibility and severity in Vietnamese
Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports
have searched for the association of host genetic variants with COVID-19, but the data are …
have searched for the association of host genetic variants with COVID-19, but the data are …
[HTML][HTML] Biobanking as a tool for genomic research: from allele frequencies to cross-ancestry association studies
TE Lazareva, YA Barbitoff, AI Changalidis… - Journal of Personalized …, 2022 - mdpi.com
In recent years, great advances have been made in the field of collection, storage, and
analysis of biological samples. Large collections of samples, biobanks, have been …
analysis of biological samples. Large collections of samples, biobanks, have been …