More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Fish are the most diversified group of vertebrates and, although progress has been made in
the past years, only relatively few fish species have been examined to date, with regards to …

Mammalian studies have shaped our understanding of the endocrine control of appetite and
body weight in vertebrates and provided the basic vertebrate model that involves central …

Background Obesity is a multifactorial disorder influenced by genetic and environmental
factors. Animal models of obesity are required to help us understand the signaling pathways …

We summarize the biological impact of leptin signaling as well as the molecular and cellular
characteristics of leptin action. Our focus is principally in the central nervous system and we …

Leptin, the protein product of the obese (ob or Lep) gene, is a hormone synthesized by
adipocytes that signals available energy reserves to the brain, and thereby influences …

In the last years, studies on stress attenuation in fish have progressively grown. This is
mainly due to the interest of institutions, producers, aquarists and consumers in improving …

Endocrine factors regulate food intake and growth, two interlinked physiological processes
critical for the proper development of organisms. Somatic growth is mainly regulated by …

Leptin is the primary adipostatic factor in mammals. Produced largely by adipocytes in
proportion to total adipose mass, the hormone informs the brain regarding total energy …