Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

[HTML][HTML] An omics-based framework for assessing the health risk of antimicrobial resistance genes

AN Zhang, JM Gaston, CL Dai, S Zhao, M Poyet… - Nature …, 2021 - nature.com
Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs
pose serious threats to public health, highlighting the importance of identifying those that are …

[HTML][HTML] Assessment of global health risk of antibiotic resistance genes

Z Zhang, Q Zhang, T Wang, N Xu, T Lu, W Hong… - Nature …, 2022 - nature.com
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in
the last decade. Many genes can confer resistance, but evaluating the relative health risks of …

[HTML][HTML] High-throughput microbial culturomics using automation and machine learning

Y Huang, RU Sheth, S Zhao, LA Cohen… - Nature …, 2023 - nature.com
Pure bacterial cultures remain essential for detailed experimental and mechanistic studies in
microbiome research, and traditional methods to isolate individual bacteria from complex …

Robust variation in infant gut microbiome assembly across a spectrum of lifestyles

MR Olm, D Dahan, MM Carter, BD Merrill, FB Yu… - Science, 2022 - science.org
Infant microbiome assembly has been intensely studied in infants from industrialized
nations, but little is known about this process in nonindustrialized populations. We deeply …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

[HTML][HTML] Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

T Vatanen, KS Jabbar, T Ruohtula, J Honkanen… - Cell, 2022 - cell.com
The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …

High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome

W Zheng, S Zhao, Y Yin, H Zhang, DM Needham… - Science, 2022 - science.org
Characterizing complex microbial communities with single-cell resolution has been a long-
standing goal of microbiology. We present Microbe-seq, a high-throughput method that …

[HTML][HTML] Public human microbiome data are dominated by highly developed countries

RJ Abdill, EM Adamowicz, R Blekhman - PLoS biology, 2022 - journals.plos.org
The importance of sampling from globally representative populations has been well
established in human genomics. In human microbiome research, however, we lack a full …