Antibiotic perturbations to the gut microbiome
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …
[HTML][HTML] An omics-based framework for assessing the health risk of antimicrobial resistance genes
Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs
pose serious threats to public health, highlighting the importance of identifying those that are …
pose serious threats to public health, highlighting the importance of identifying those that are …
[HTML][HTML] Assessment of global health risk of antibiotic resistance genes
Z Zhang, Q Zhang, T Wang, N Xu, T Lu, W Hong… - Nature …, 2022 - nature.com
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in
the last decade. Many genes can confer resistance, but evaluating the relative health risks of …
the last decade. Many genes can confer resistance, but evaluating the relative health risks of …
[HTML][HTML] High-throughput microbial culturomics using automation and machine learning
Pure bacterial cultures remain essential for detailed experimental and mechanistic studies in
microbiome research, and traditional methods to isolate individual bacteria from complex …
microbiome research, and traditional methods to isolate individual bacteria from complex …
Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Infant microbiome assembly has been intensely studied in infants from industrialized
nations, but little is known about this process in nonindustrialized populations. We deeply …
nations, but little is known about this process in nonindustrialized populations. We deeply …
[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
[HTML][HTML] Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
T Vatanen, KS Jabbar, T Ruohtula, J Honkanen… - Cell, 2022 - cell.com
The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …
High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome
W Zheng, S Zhao, Y Yin, H Zhang, DM Needham… - Science, 2022 - science.org
Characterizing complex microbial communities with single-cell resolution has been a long-
standing goal of microbiology. We present Microbe-seq, a high-throughput method that …
standing goal of microbiology. We present Microbe-seq, a high-throughput method that …
[HTML][HTML] Public human microbiome data are dominated by highly developed countries
The importance of sampling from globally representative populations has been well
established in human genomics. In human microbiome research, however, we lack a full …
established in human genomics. In human microbiome research, however, we lack a full …