Diabetic neuropathies (DNs) differ in clinical course, distribution, fiber involvement (type and
size), and pathophysiology, the most typical type being a length-dependent distal symmetric …

One of the most overlooked of all serious complications of diabetes is cardiovascular
autonomic neuropathy. There is now clear evidence that suggests activation of inflammatory …

Objective: Sudomotor dysfunction may be an early detectable abnormality in diabetic small
fiber neuropathy. The aim of this study was to evaluate the efficacy of Sudoscan™(Impeto …

RAGE, the receptor of advanced glycation end-products, is thought to be one of the potential
contributors to the neurodegeneration. It has been shown that RAGE activation triggers an …

The multi-ligand receptor RAGE was discovered on account of its ability to bind and
transduce the cell stress-provoking signals of advanced glycation endproducts (AGEs). The …

Cardiovascular autonomic neuropathy (CAN) in diabetes is generally overlooked in practice,
although awareness of its serious consequences is emerging. Challenges in understanding …

Charcot foot syndrome is an uncommon complication of diabetes but is potentially
devastating in its consequences. Outcome is made worse by widespread professional …

Charcot neuroarthropathy is a limb-threatening, destructive process that occurs in patients
with neuropathy associated with medical diseases such as diabetes mellitus. Clinicians' …

Bad bedfellows–autonomic dysfunction, inflammation, and diabetes! Are they related? How?
Evidence suggests the activation of inflammatory cytokines like IL-6 and TNFα in newly …

This book presents the concepts underlying the measurement of parasympathetic and
sympathetic (P&S) activity in the autonomic nervous system and the application of these …