Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

The importance of glucose‐dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

LS Gasbjerg, MM Rosenkilde, JJ Meier… - Diabetes, Obesity …, 2023 - Wiley Online Library
Tirzepatide is a unimolecular co‐agonist of the glucagon‐like peptide‐1 (GLP‐1) and
glucose‐dependent insulinotropic polypeptide (GIP) receptors recently approved for the …

Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement

DE Forman, GA Kuchel, JC Newman… - Journal of the American …, 2023 - jacc.org
Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result
from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age …

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke? Discordance between randomised controlled trials and observational studies

AJ Scheen - Diabetes & Metabolism, 2023 - Elsevier
Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular
complication has been less carefully investigated than the risk of cardiovascular mortality …

[HTML][HTML] SGLT2 inhibitors in chronic kidney disease: from mechanisms to clinical practice

R Skrabic, M Kumric, J Vrdoljak, D Rusic, I Skrabic… - Biomedicines, 2022 - mdpi.com
In recent years, sodium-glucose co-transporter 2 inhibitors (SGLT2i) have demonstrated
beneficial renoprotective effects, which culminated in the recent approval of their use for …

[HTML][HTML] The extraglycemic effect of SGLT-2is on mineral and bone metabolism and bone fracture

B Dong, R Lv, J Wang, L Che, Z Wang, Z Huai… - Frontiers in …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporosis. The effects of T2DM and
anti-diabetic agents on bone and mineral metabolism have been observed. Sodium …

[HTML][HTML] New hypoglycemic drugs: combination drugs and targets discovery

X Ni, L Zhang, X Feng, L Tang - Frontiers in pharmacology, 2022 - frontiersin.org
New hypoglycemic drugs, including glucagon-like peptide 1 receptor agonists (GLP-1RA),
dipeptidyl peptidase-4 inhibitors (DPP-4i) and sodium-glucose cotransporter 2 inhibitors …

Dipeptidyl peptidase-4 inhibitors and gallbladder or biliary disease in type 2 diabetes: systematic review and pairwise and network meta-analysis of randomised …

L He, J Wang, F Ping, N Yang, J Huang, W Li, L Xu… - bmj, 2022 - bmj.com
Objective To examine the association between dipeptidyl peptidase-4 inhibitors and
gallbladder or biliary diseases. Design Systematic review and pairwise and network meta …

Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological …

P Ferdinandy, I Andreadou, GF Baxter, HE Bøtker… - Pharmacological …, 2023 - ASPET
Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Association between metabolic dysfunction-associated fatty liver disease and supraventricular and ventricular tachyarrhythmias in patients with type 2 diabetes

A Mantovani, A Csermely, A Taverna, D Cappelli… - Diabetes & …, 2023 - Elsevier
Background Currently, it remains uncertain whether metabolic dysfunction-associated fatty
liver disease (MAFLD) is associated with increased risk of supraventricular and ventricular …