It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2
mega-Daltons. These channels mediate calcium signaling in a variety of cells. Since more …

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disorder characterized by adrenergically mediated polymorphic ventricular …

Ryanodine receptors are large channels that release Ca2+ from the endoplasmic and
sarcoplasmic reticulum. Hundreds of RyR mutations can cause cardiac and skeletal muscle …

Ryanodine-sensitive Ca2 release channels, also known as the ryanodine receptors (RyRs),
2 are homotetramers of an 550-kDa subunit (Fig. 1) that are resident proteins of intracellular …

Here we review the current knowledge about the mutations of the gene encoding the cardiac
ryanodine receptor (RyR2) that cause cardiac arrhythmias. Similarities between the …

Ryanodine receptors (RyR) function as Ca2+ channels that regulate Ca2+ release from
intracellular stores to control a diverse array of cellular processes. The massive cytoplasmic …

In previous studies we have suggested that spatial proximity of the C-and N-terminal
domains of inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) may be critical for the channel …