DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …

Deficiencies in the standard preclinical methods for evaluating potential anticancer drugs,
such as xenograft mouse models, have been highlighted as a key obstacle in the translation …

Evidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension
by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer. To …

Obesity is associated with increased classically activated M1 adipose tissue macrophages
(ATMs) and decreased alternatively activated M2 ATMs, both of which contribute to obesity …

Dicer initiates RNA interference by generating small RNAs involved in various silencing
pathways. Dicer participates in centromeric silencing, but its role in the epigenetic regulation …

Growing evidence suggests epigenetic alteration is involved during the development and
progression of prostate cancer. Previously, we found Nrf2, a key regulator of cellular …

Objectives Activated Wnt signalling with decreased expression of endogenous inhibitors has
recently been characterised as a central pathomechanism in systemic sclerosis (SSc) …

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is a transcription factor which regulates
the expression of many cytoprotective genes. In the present study, we found that the …

The first in vivo tumor models were developed in the mid-1960s. These models were mouse
leukemia models grown as ascites. The growth pattern was like that of bacteria in vivo and …