This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Background & Aims Histamine sensitizes the nociceptor transient reporter potential channel
V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We …

Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following
abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …