In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …

Trypanosomes have complex life cycles within which there are both proliferative and
differentiation cell divisions. The coordination of the cell cycle to achieve these different …

Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually
associated with adaptation to stress conditions. Chromosomal duplication stability is a …

Trypanosomatids, which include major pathogens of humans and livestock, are flagellated
protozoa for which cell cycle controls and the underlying mechanisms are not completely …

DNA replication is needed to duplicate a cell's genome in S phase and segregate it during
cell division. Previous work in Leishmania detected DNA replication initiation at just a single …

R-loops are stable RNA–DNA hybrids that have been implicated in transcription initiation
and termination, as well as in telomere maintenance, chromatin formation, and genome …

Homologous recombination (HR) has an intimate relationship with genome replication, both
during repair of DNA lesions that might prevent DNA synthesis and in tackling stalls to the …

The genomes of all organisms are read throughout their growth and development,
generating new copies during cell division and encoding the cellular activities dictated by …

Damaged DNA typically imposes stringent controls on eukaryotic cell cycle progression,
ensuring faithful transmission of genetic material. Some DNA breaks, and the resulting …

Although aneuploidy usually results in severe abnormalities in multicellular eukaryotes,
recent data suggest that it could be beneficial for unicellular eukaryotes, such as yeast and …