Plant glutamate receptor-like (GLR) genes encode ion channels with demonstrated roles in
electrical and calcium (Ca2+) signaling. The expansion of the GLR family along the lineage …

Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …

Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …

Intrinsically disordered proteins (IDPs) populate a range of conformations that are best
described by a heterogeneous ensemble. Grouping an IDP ensemble into “structurally …

Kainate receptors (KARs) are a subtype of ionotropic glutamate receptors that control
synaptic transmission in the central nervous system and are implicated in neurological …

Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …

Calcium is a highly positively charged ionic species. It regulates all cell types' functions and
is an important second messenger that controls and triggers several mechanisms, including …

N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …