Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research
Neurodegenerative diseases are commonly associated with the formation of aberrant
protein aggregates within the brain, and ultrastructural analyses have revealed that the …
protein aggregates within the brain, and ultrastructural analyses have revealed that the …
Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways
KM Dewison, B Rowlinson, JM Machin… - Proceedings of the …, 2024 - pnas.org
Amyloid formation by α-synuclein (αSyn) occurs in Parkinson's disease, multiple system
atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate αSyn …
atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate αSyn …
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
D Pérez-Acuña, SJ Shin, KH Rhee, SJ Kim, SJ Lee - Molecular brain, 2023 - Springer
The major neuropathologic feature of Parkinson's disease is the presence of widespread
intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these …
intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these …
[HTML][HTML] From Basic Mechanisms and Cellular Machineries to AI Solutions in Protein Folding: Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid …
KM Dewison, B Rowlinson, JM Machin… - Proceedings of the …, 2024 - pmc.ncbi.nlm.nih.gov
In Vitro. The bioinformatic analyses conducted in our previous study that identified P1
(residues 36 to 42) and P2 (residues 45 to 57) as important regulatory regions for αSyn …
(residues 36 to 42) and P2 (residues 45 to 57) as important regulatory regions for αSyn …
Exploring the Interaction of Human α-Synuclein with Polyethylene Nanoplastics: Insights from Computational Modeling and Experimental Corroboration
N Tripathi, F Saudrais, M Rysak, L Pieri, S Pin… - …, 2024 - ACS Publications
Plastics, particularly microplastics (MPs) and nanoplastics (NP), have become major
environmental and health concerns due to their high chemical stability. The highly …
environmental and health concerns due to their high chemical stability. The highly …
Residues 2-7 of alpha-synuclein regulate amyloid formation via lipid-dependent and-independent pathways
KM Dewison, B Rowlinson, JM Machin, JA Crossley… - bioRxiv, 2024 - biorxiv.org
Amyloid formation by alpha-synuclein (alphaSyn) occurs in Parkinsons disease, multiple
system atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate …
system atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate …
Global kinetic model of lipid-induced alpha-synuclein aggregation and its inhibition by small molecules
The aggregation of alpha-synuclein into amyloid fibrils is a hallmark of Parkinson's disease.
This process has been shown to directly involve interactions between proteins and lipid …
This process has been shown to directly involve interactions between proteins and lipid …
Studies on Retina-to-Brain spreading of α-synuclein pathology and cortical synaptic dysfunction in a propagation model of Parkinsons disease
다야나 - 2024 - s-space.snu.ac.kr
Parkinsons disease (PD) is a progressive neurodegenerative disorder characterized by the
abnormal accumulation of α-synuclein in the brain that triggers a series of neuropathological …
abnormal accumulation of α-synuclein in the brain that triggers a series of neuropathological …