Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
Intracerebral hemorrhage, oxidative stress, and antioxidant therapy
X Duan, Z Wen, H Shen, M Shen… - Oxidative medicine and …, 2016 - Wiley Online Library
Hemorrhagic stroke is a common and severe neurological disorder and is associated with
high rates of mortality and morbidity, especially for intracerebral hemorrhage (ICH) …
high rates of mortality and morbidity, especially for intracerebral hemorrhage (ICH) …
Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol
S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
Neuroprotection of NRF2 against ferroptosis after traumatic brain injury in mice
H Cheng, P Wang, N Wang, W Dong, Z Chen, M Wu… - Antioxidants, 2023 - mdpi.com
Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI)
outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and …
outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and …
Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals
AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …
The controlled cortical impact model: applications, considerations for researchers, and future directions
ND Osier, CE Dixon - Frontiers in neurology, 2016 - frontiersin.org
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …
was developed nearly 30 years ago with the goal of creating a testing platform to determine …
The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway
Q Hu, J Ren, G Li, J Wu, X Wu, G Wang, G Gu… - Cell death & …, 2018 - nature.com
Disruption of the mucosal barrier following intestinal ischemia reperfusion (I/R) is life
threatening in clinical practice. Mitochondrial dysfunction and oxidative stress significantly …
threatening in clinical practice. Mitochondrial dysfunction and oxidative stress significantly …
Criteria to define mild, moderate, and severe traumatic brain injury in the mouse controlled cortical impact model
Traumatic brain injury (TBI) is a major health concern in the United States resulting in a
substantial number of hospitalizations and in a broad spectrum of symptoms and disabilities …
substantial number of hospitalizations and in a broad spectrum of symptoms and disabilities …
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling
W Dong, B Yang, L Wang, B Li, X Guo, M Zhang… - Toxicology and applied …, 2018 - Elsevier
Traumatic brain injury (TBI), which leads to high mortality and morbidity, is a prominent
public health problem worldwide with no effective treatment. Curcumin has been shown to …
public health problem worldwide with no effective treatment. Curcumin has been shown to …
Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities
Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …