Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Intracerebral hemorrhage, oxidative stress, and antioxidant therapy

X Duan, Z Wen, H Shen, M Shen… - Oxidative medicine and …, 2016 - Wiley Online Library
Hemorrhagic stroke is a common and severe neurological disorder and is associated with
high rates of mortality and morbidity, especially for intracerebral hemorrhage (ICH) …

Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol

S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …

Neuroprotection of NRF2 against ferroptosis after traumatic brain injury in mice

H Cheng, P Wang, N Wang, W Dong, Z Chen, M Wu… - Antioxidants, 2023 - mdpi.com
Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI)
outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …

The controlled cortical impact model: applications, considerations for researchers, and future directions

ND Osier, CE Dixon - Frontiers in neurology, 2016 - frontiersin.org
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

Q Hu, J Ren, G Li, J Wu, X Wu, G Wang, G Gu… - Cell death & …, 2018 - nature.com
Disruption of the mucosal barrier following intestinal ischemia reperfusion (I/R) is life
threatening in clinical practice. Mitochondrial dysfunction and oxidative stress significantly …

Criteria to define mild, moderate, and severe traumatic brain injury in the mouse controlled cortical impact model

L Siebold, A Obenaus, R Goyal - Experimental neurology, 2018 - Elsevier
Traumatic brain injury (TBI) is a major health concern in the United States resulting in a
substantial number of hospitalizations and in a broad spectrum of symptoms and disabilities …

Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling

W Dong, B Yang, L Wang, B Li, X Guo, M Zhang… - Toxicology and applied …, 2018 - Elsevier
Traumatic brain injury (TBI), which leads to high mortality and morbidity, is a prominent
public health problem worldwide with no effective treatment. Curcumin has been shown to …

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

B Hakiminia, B Alikiaii, F Khorvash… - Fundamental & …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …