Single‐cell RNA‐seq has enabled gene expression to be studied at an unprecedented
resolution. The promise of this technology is attracting a growing user base for single‐cell …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a
crucial role in the entry of virus into the cell to cause the final infection. To investigate the …

We perform a thorough analysis of RNA velocity methods, with a view towards
understanding the suitability of the various assumptions underlying popular …

The immune system varies in cell types, states, and locations. The complex networks,
interactions, and responses of immune cells produce diverse cellular ecosystems composed …

Background Pancreatic ductal adenocarcinoma (PDAC) is most aggressive among all
gastrointestinal tumors. The complex intra-tumor heterogeneity and special tumor …

RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative
analysis of messenger RNA molecules in a biological sample and is useful for studying …

As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the
number of tools designed to analyse these data has dramatically increased. Navigating the …

Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …

Motivation Single-cell RNA-seq makes possible the investigation of variability in gene
expression among cells, and dependence of variation on cell type. Statistical inference …