Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications

D Carnevale - Nature Reviews Cardiology, 2022 - nature.com
Cardiovascular diseases (CVDs) make a substantial contribution to the global burden of
disease. Prevention strategies have succeeded in reducing the effect of acute CVD events …

Vasopressin and breathing: review of evidence for respiratory effects of the antidiuretic hormone

M Proczka, J Przybylski… - Frontiers in Plant …, 2021 - frontiersin.org
Vasopressin (AVP) is a key neurohormone involved in the regulation of body functions. Due
to its urine-concentrating effect in the kidneys, it is often referred to as antidiuretic hormone …

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways

RA Piñol, AS Mogul, CK Hadley, A Saha, C Li, V Škop… - Cell metabolism, 2021 - cell.com
The preoptic area (POA) is a key brain region for regulation of body temperature (Tb),
dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previously …

Identification of novel cross-talk between the neuroendocrine and autonomic stress axes controlling blood pressure

K Elsaafien, MK Kirchner, M Mohammed… - Journal of …, 2021 - Soc Neuroscience
The hypothalamic paraventricular nucleus (PVN) controls neuroendocrine axes and the
autonomic nervous system to mount responses that cope with the energetic burdens of …

WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release

X Jin, J Xie, CW Yeh, JC Chen… - The Journal of …, 2023 - Am Soc Clin Investig
Maintaining internal osmolality constancy is essential for life. Release of arginine
vasopressin (AVP) in response to hyperosmolality is critical. Current hypotheses for …

Cardiovascular neuroendocrinology: emerging role for neurohypophyseal hormones in pathophysiology

AO Aikins, DH Nguyen, O Paundralingga… - …, 2021 - academic.oup.com
Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular
neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently …

Role of inflammatory processes in the brain-body relationship underlying hypertension

D Carnevale - Current Hypertension Reports, 2023 - Springer
Abstract Purpose of Review Essential hypertension is a huge health problem that
significantly impacts worldwide population in terms of morbidity and mortality. Idiopathic in …

Sodium intake and disease: another relationship to consider

C Baumer-Harrison, JM Breza, C Sumners, EG Krause… - Nutrients, 2023 - mdpi.com
Sodium (Na+) is crucial for numerous homeostatic processes in the body and,
consequentially, its levels are tightly regulated by multiple organ systems. Sodium is …

A novel organ-specific approach to selectively target sensory afferents innervating the aortic arch

K Elsaafien, SW Harden, DN Johnson… - Frontiers in …, 2022 - frontiersin.org
The brain maintains cardiovascular homeostasis, in part, via the arterial baroreflex which
senses changes in blood pressure (BP) at the level of the aortic arch. Sensory afferents …

Activation of the organum vasculosum of the lamina terminalis produces a sympathetically mediated hypertension

SD Stocker, MM Wenner, WB Farquhar… - Hypertension, 2022 - Am Heart Assoc
Neurons in the organum vasculosum of the lamina terminalis (OVLT) sense extracellular
NaCl and angiotensin II concentrations to regulate body fluid homeostasis and arterial blood …