Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …

Cholesterol is a central building block in biomembranes, where it induces orientational
order, slows diffusion, renders the membrane stiffer, and drives domain formation. Molecular …

Lipids rafts are considered to be functional nanoscale membrane domains enriched in
cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell …

There is evidence that lipids can be allosteric regulators of membrane protein structure and
activation. However, there are no data showing how exactly the regulation emerges from …

We report parametrization of dipalmitoyl-phosphatidylcholine (DPPC) in the framework of
the Optimized Parameters for Liquid Simulations all-atom (OPLS-AA) force field. We chose …

A rich diversity of transmembrane G protein-coupled receptors (GPCRs) are used by
eukaryotes to sense physical and chemical signals. In humans alone, 800 GPCRs comprise …

Membrane bilayers are made up of a myriad of different lipids that regulate the functional
activity, stability, and oligomerization of many membrane proteins. Despite their importance …

G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …

Mapping the conformational landscape of G protein-coupled receptors (GPCRs), and in
particular how this landscape is modulated by the membrane environment, is required to …