The role of protein loops and linkers in conformational dynamics and allostery
Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …
take place on a wide range of time scales. These changes can be as small as the rotation of …
Transcription-mediated replication hindrance: a major driver of genome instability
B Gómez-González, A Aguilera - Genes & development, 2019 - genesdev.cshlp.org
Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex
SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 genome
is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme …
is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme …
A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery
In prokaryotes, translation can occur on mRNA that is being transcribed in a process called
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …
Conflict resolution in the genome: how transcription and replication make it work
S Hamperl, KA Cimprich - Cell, 2016 - cell.com
The complex machineries involved in replication and transcription translocate along the
same DNA template, often in opposing directions and at different rates. These processes …
same DNA template, often in opposing directions and at different rates. These processes …
Evolution of multisubunit RNA polymerases in the three domains of life
F Werner, D Grohmann - Nature Reviews Microbiology, 2011 - nature.com
RNA polymerases (RNAPs) carry out transcription in all living organisms. All multisubunit
RNAPs are derived from a common ancestor, a fact that becomes apparent from their amino …
RNAPs are derived from a common ancestor, a fact that becomes apparent from their amino …
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
M Bouvet, I Imbert, L Subissi, L Gluais… - Proceedings of the …, 2012 - National Acad Sciences
The replication/transcription complex of severe acute respiratory syndrome coronavirus is
composed of at least 16 nonstructural proteins (nsp1–16) encoded by the ORF-1a/1b. This …
composed of at least 16 nonstructural proteins (nsp1–16) encoded by the ORF-1a/1b. This …
Structure and mechanism of the RNA polymerase II transcription machinery
S Hahn - Nature structural & molecular biology, 2004 - nature.com
Advances in structure determination of the bacterial and eukaryotic transcription machinery
have led to a marked increase in the understanding of the mechanism of transcription …
have led to a marked increase in the understanding of the mechanism of transcription …
Architecture of a transcribing-translating expressome
R Kohler, RA Mooney, DJ Mills, R Landick, P Cramer - Science, 2017 - science.org
DNA transcription is functionally coupled to messenger RNA (mRNA) translation in bacteria,
but how this is achieved remains unclear. Here we show that RNA polymerase (RNAP) and …
but how this is achieved remains unclear. Here we show that RNA polymerase (RNAP) and …
Elongation by RNA polymerase II: the short and long of it
RJ Sims, R Belotserkovskaya… - Genes & …, 2004 - genesdev.cshlp.org
Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …
II) have identified this stage as a dynamic and highly regulated step of the transcription …