[HTML][HTML] Extracellular vesicle activities regulating macrophage-and tissue-mediated injury and repair responses

Q Hu, CJ Lyon, JK Fletcher, W Tang, M Wan… - … Pharmaceutica Sinica B, 2021 - Elsevier
Macrophages are typically identified as classically activated (M1) macrophages and
alternatively activated (M2) macrophages, which respectively exhibit pro-and anti …

Non-coding RNAs and exosomes: their role in the pathogenesis of sepsis

SMR Hashemian, MH Pourhanifeh, S Fadaei… - … Therapy-Nucleic Acids, 2020 - cell.com
Sepsis is characterized as an uncontrolled host response to infection, and it represents a
serious health challenge, causing excess mortality and morbidity worldwide. The discovery …

Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?

AS Abouhashem, K Singh, HME Azzazy, CK Sen - 2020 - liebertpub.com
Human lungs single-cell RNA sequencing data from healthy donors (elderly and young;
GEO accession no. GSE122960) were analyzed to isolate and specifically study gene …

Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1

N Ghosh, A Das, N Biswas, S Gnyawali, K Singh… - Scientific Reports, 2020 - nature.com
Urolithin A (UA) is a natural compound that is known to improve muscle function. In this work
we sought to evaluate the effect of UA on muscle angiogenesis and identify the underlying …

Extracellular vesicles: A double-edged sword in sepsis

M Burgelman, C Vandendriessche… - Pharmaceuticals, 2021 - mdpi.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. Several studies on mouse and patient sepsis samples have …

Adult skin fibroblast state change in murine wound healing

FZ Gharbia, AS Abouhashem, YA Moqidem… - Scientific Reports, 2023 - nature.com
Wound healing is a well-organized dynamic process involving coordinated consecutive
phases: homeostasis, inflammation, proliferation and resolution. Fibroblasts play major roles …

Extracellular vesicles participate in the pathogenesis of sepsis

C Tian, K Wang, M Zhao, S Cong, X Di… - Frontiers in Cellular and …, 2022 - frontiersin.org
Sepsis is one of the leading causes of mortality worldwide and is defined as life-threatening
organ dysfunction caused by a dysregulated host response to infection. The early diagnosis …

Advances and challenges in sepsis management: modern tools and future directions

E Santacroce, M D'Angerio, AL Ciobanu, L Masini… - Cells, 2024 - mdpi.com
Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate
and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare …

Pathogenesis of multiple organ failure: the impact of systemic damage to plasma membranes

AV Kozlov, J Grillari - Frontiers in medicine, 2022 - frontiersin.org
Multiple organ failure (MOF) is the major cause of morbidity and mortality in intensive care
patients, but the mechanisms causing this severe syndrome are still poorly understood …

The roles of extracellular vesicles in sepsis and systemic inflammatory response syndrome

B Weber, D Henrich, F Hildebrand, I Marzi, L Leppik - Shock, 2023 - journals.lww.com
Sepsis is a life-threatening organ dysfunction, caused by dysregulation of the host response
to infection. To understand the underlying mechanisms of sepsis, the vast spectrum of …