The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …

Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that
mediate important regulatory signals in the cell. Three major groups of Map kinases exist …

Immortalized cell lines are widely used in vitro tools in oncology and hematology research.
While these cell lines represent artificial systems and may accumulate genetic aberrations …

The JNK signaling pathway is involved in regulation of many cellular events, including
growth control, transformation and programmed cell death (apoptosis). The role of JNK …

Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of
myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an …

Zosuquidar, which modulates P-glycoprotein (P-gp) with minimal delay of anthracycline
clearance, may reverse P-gp–mediated resistance in acute myeloid leukemia without …

Abstract MRP1 (ABCC1) is a peculiar member of the ABC transporter superfamily for several
aspects. This protein has an unusually broad substrate specificity and is capable of …

Abstract The multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), and the
multidrug resistance–related proteins (MRPs) are members of the adenosine triphosphate …

The activating transcription factor 2 (ATF2) is a member of the ATF/cAMP-response element-
binding protein family of basic-leucine zipper proteins involved in cellular stress response …

WO WO 2006/053121 A2 5, 2006 WO WO 2006/053121 A3 5, 2006 WO WO 2006/076592
A1 T 2006 WO WO 2006/0990.75 A2 9, 2006 WO WO 2006/0990.75 A3 9, 2006 WO WO …