Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

The three main soil-transmitted helminth infections, ascariasis, trichuriasis, and hookworm,
are common clinical disorders in man. The gastrointestinal tract of a child living in poverty in …

Adolescence is a developmental period in which the mesolimbic dopaminergic “reward”
circuitry of the brain, including the nucleus accumbens (NAc), undergoes significant …

Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

In areas of rural poverty in the tropics and subtropics, more than 700 million persons are
infected with the parasites Necator americanus and Ancylostoma duodenale. The adult …

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most
prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides …

Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal
harm to their hosts, allowing them to establish chronic infections. This is mediated by …

The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)
superfamily members are found in a remarkable range of organisms spanning each of the …

We have determined the high resolution crystal structure of the A domain from the a chain of
integrin CR3. The domain adopts a classic α/β “Rossmann” fold and contains an unusual …

The scientific study of human hookworm infection began at the dawn of the twentieth
century. In recent years, there have been dramatic improvements in our understanding of …