GLP− 1 receptor agonists for the treatment of obesity: Role as a promising approach

JY Wang, QW Wang, XY Yang, W Yang… - Frontiers in …, 2023 - frontiersin.org
Obesity is a complex disease characterized by excessive fat accumulation which is caused
by genetic, environmental and other factors. In recent years, there has been an increase in …

GLP-1 analogs and DPP-4 inhibitors in type 2 diabetes therapy: review of head-to-head clinical trials

MP Gilbert, RE Pratley - Frontiers in endocrinology, 2020 - frontiersin.org
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are released from enteroendocrine cells in response to the …

Anti-diabetic drugs and weight loss in patients with type 2 diabetes

E Lazzaroni, MB Nasr, C Loretelli, I Pastore… - Pharmacological …, 2021 - Elsevier
Introduction Obesity is frequently a comorbidity of type 2 diabetes. Even modest weight loss
can significantly improve glucose homeostasis and lessen cardiometabolic risk factors in …

Management of endocrine disease: are all GLP-1 agonists equal in the treatment of type 2 diabetes?

MA Nauck, JJ Meier - European journal of endocrinology, 2019 - academic.oup.com
GLP-1, a peptide hormone secreted from the gut, stimulating insulin and suppressing
glucagon secretion was identified as a parent compound for novel treatments of diabetes …

Efficacy and safety of glucagon‐like peptide‐1 receptor agonists in type 2 diabetes: a systematic review and mixed‐treatment comparison analysis

ZZ Htike, F Zaccardi, D Papamargaritis… - Diabetes, Obesity …, 2017 - Wiley Online Library
Aims To compare efficacy and safety of glucagon‐like peptide‐1 receptor agonists (GLP‐
1RAs) in people with type 2 diabetes. Materials and methods We electronically searched, up …

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

AA Tahrani, AH Barnett, CJ Bailey - Nature Reviews Endocrinology, 2016 - nature.com
Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-
care systems. Improving metabolic control to approach normal glycaemia (where practical) …

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

JJ Meier - Nature Reviews Endocrinology, 2012 - nature.com
In healthy humans, the incretin glucagon-like peptide 1 (GLP-1) is secreted after eating and
lowers glucose concentrations by augmenting insulin secretion and suppressing glucagon …

Obesity‐related hypertension: Pathogenesis, cardiovascular risk, and treatment—A position paper of the The Obesity Society and the American Society of …

L Landsberg, LJ Aronne, LJ Beilin, V Burke, LI Igel… - …, 2013 - Wiley Online Library
In light of the worldwide epidemic of obesity, and in recognition of hypertension as a major
factor in the cardiovascular morbidity and mortality associated with obesity, The Obesity …

A review of GLP‐1 receptor agonists: evolution and advancement, through the lens of randomised controlled trials

VR Aroda - Diabetes, Obesity and Metabolism, 2018 - Wiley Online Library
Aims To review the evolution and advancement of GLP‐1 receptor agonist (GLP‐1RA)
therapy, through the lens of randomised controlled trials, from differentiating characteristics …

Adverse effects of GLP-1 receptor agonists

TD Filippatos, TV Panagiotopoulou… - The review of diabetic …, 2015 - pmc.ncbi.nlm.nih.gov
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of injective anti-diabetic
drugs that improve glycemic control and many other atherosclerosis-related parameters in …