Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine
Extracellular matrix is rich in biomolecules including structural proteins,
glycosaminoglycans, and small molecules that are important for the maintenance and repair …
glycosaminoglycans, and small molecules that are important for the maintenance and repair …
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …
of most organoid tissue culture. However, it has limited the utility of organoids for drug …
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro
model to recapitulate human brain development and neurological diseases. However, the …
model to recapitulate human brain development and neurological diseases. However, the …
Decellularized extracellular matrix-based bioinks for engineering tissue-and organ-specific microenvironments
Biomaterials-based biofabrication methods have gained much attention in recent years.
Among them, 3D cell printing is a pioneering technology to facilitate the recapitulation of …
Among them, 3D cell printing is a pioneering technology to facilitate the recapitulation of …
Extracellular matrix-based materials for regenerative medicine
GS Hussey, JL Dziki, SF Badylak - Nature Reviews Materials, 2018 - nature.com
In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …
and biochemical signals to encourage cell attachment and modulate cell behaviour …
Extracellular matrix hydrogels from decellularized tissues: Structure and function
Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been
used to facilitate constructive and functional tissue remodeling in a variety of clinical …
used to facilitate constructive and functional tissue remodeling in a variety of clinical …
Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture
Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and
progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands …
progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands …
Extracellular matrix hydrogel therapies: In vivo applications and development
MT Spang, KL Christman - Acta biomaterialia, 2018 - Elsevier
Decellularized extracellular matrix (ECM) has been widely used for tissue engineering
applications and is becoming increasingly versatile as it can take many forms, including …
applications and is becoming increasingly versatile as it can take many forms, including …
Designing decellularized extracellular matrix‐based bioinks for 3D bioprinting
A Abaci, M Guvendiren - Advanced healthcare materials, 2020 - Wiley Online Library
Abstract 3D bioprinting is an emerging technology to fabricate tissues and organs by
precisely positioning cells into 3D structures using printable cell‐laden formulations known …
precisely positioning cells into 3D structures using printable cell‐laden formulations known …