KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

In the heart, Ca2+ influx via CaV1. 2 L-type calcium channels (LTCCs) is a multi-functional
signal that triggers muscle contraction, controls action potential duration, and regulates gene …

During each heartbeat, intercellular electrical coupling via connexin43 (Cx43) gap junctions
enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces …

BACKGROUND: Heart failure is a growing epidemic, and a typical aspect of heart failure
pathophysiology is altered calcium transients. Normal cardiac calcium transients are …

Rationale: The intracellular trafficking of connexin 43 (Cx43) hemichannels presents
opportunities to regulate cardiomyocyte gap junction coupling. Although it is known that …

Background Aging is related to declined cardiac hemodynamic function. As pumping
performance may be significantly related to slowed ventricular depolarization and non …

It is widely assumed that synthesis of membrane proteins, particularly in the heart, follows
the classical secretory pathway with mRNA translation occurring in perinuclear regions …

Histone deacetylase (HDAC) inhibitors are an emerging class of anticancer agents that
modify gene expression by altering the acetylation status of lysine residues of histone …

Transcribed messenger RNA of the connexin 43 gene (Gja1) is translated to the connexin
43 protein by ribosomes and translocated through the membrane of the rough ER, the …

Transient receptor potential melastatin 4 (TRPM4) is a Ca2+‐activated nonselective cationic
channel involved in a wide variety of physiologic and pathophysiological processes …