Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor
effects are not always satisfactory due to the limited penetration and retention. As we all …

Inflammation is intimately related to the pathogenesis of numerous acute and chronic
diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and …

Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

As a ROS scavenger, resveratrol exerts a neuroprotective effect by polarizing the M1
microglia to the anti-inflammatory M2 phenotype for ischemic stroke treatment. However, the …

Stroke is a primary cause of death and disability worldwide, while effective and safe drugs
remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle …

In recent years, brain diseases have seriously threatened human health due to their high
morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic …

The poor drug delivery to cerebral ischemic regions is a key challenge of ischemic stroke
treatment. Inspired by the intriguing blood–brain barrier (BBB)-penetrating ability of 4T1 …

Overproduction of reactive oxygen species by damaged mitochondria after ischemia is a key
factor in the subsequent cascade of damage. Delivery of therapeutic agents to the …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

Rational design of nanomedicine to accelerate thrombolysis and sequentially avoid
thrombolysis-mediated reperfusion injury is still a challenge. Here, we develop a biomimetic …