The integration and control of systemic immune responses depends on the regulated
trafficking of lymphocytes. This lymphocyte “homing” process disperses the immunologic …

Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-
linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

The development of lymphoid organs can be viewed as a continuum. At one end are
the'canonical'secondary lymphoid organs, including lymph nodes and spleen; at the other …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally
a problem of concern only to immunologists. With the discovery of l-selectin and its ligands …

The selectin family of adhesion molecules mediates the initial attachment of leukocytes to
venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury …

To determine the site and mechanism of suppression by regulatory T (Treg) cells, we
investigated their migration and function in an islet allograft model. Treg cells first migrated …

High endothelial venules (HEVs? are specialized postcapillary venules found in lymphoid
tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean …

Sialic acids (Sias) are terminal components of many glycoproteins and glycolipids especially
of higher animals. In this exposed position they contribute significantly to the structural …